Gene–environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis
| Autor: | Cosimo Maggiore, A. Bosco, Bianca Weinstock-Guttman, Maria Antonietta Tommasi, Laura Uxa, Bhooma Srinivasaraghavan, Marino Zorzon, Robert Zivadinov, Alessio Bratina, Maurizia Serafin, Attilio Grop, Murali Ramanathan |
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| Přispěvatelé: | Zivadinov, R, WEINSTOCK GUTTMAN, B, Zorzon, Marino, Uxa, L, Serafin, M, Bosco, A, Bratina, A, Maggiore, C, Grop, A, Tommasi, Ma, Srinivasaraghavan, B, Ramanathan, M. |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Pathology medicine.medical_specialty Multiple Sclerosis Immunology Human leukocyte antigen Environment Antibodies Viral medicine.disease_cause Severity of Illness Index Immunoglobulin G HLA-B7 Antigen Antigen hemic and lymphatic diseases HLA-A2 Antigen medicine Humans Immunology and Allergy Genetic Predisposition to Disease Expanded Disability Status Scale biology Multiple sclerosis Brain Middle Aged medicine.disease Magnetic Resonance Imaging Epstein–Barr virus Neurology Immunoglobulin M biology.protein Female Neurology (clinical) Antibody Biomarkers |
| Zdroj: | Journal of Neuroimmunology. 209:123-130 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2009.01.023 |
| Popis: | Purpose To determine the role of gene–environmental interactions between the Class I and Class II HLA alleles and the humoral anti-Epstein–Barr Virus (EBV) responses in the development of brain injury and clinical disability in multiple sclerosis (MS) patients. Methods A total of 93 MS patients (62 females; 31 males) and 122 healthy controls underwent HLA typing and testing for antibodies against EBV. The MS patients underwent brain MRI and quantitative measurements of T1- and T2-lesion volumes (LVs) and brain parenchymal fraction (BPF) were obtained. There were 54 MS cases that underwent MRI and EBV-antibody assessments at the 3-year follow-up. The anti-EBV panel included measurements of the levels of anti-EBV early antigen (EA) IgG, anti-EBV nuclear antigen (EBNA) IgG and anti-EBV viral capsid antigen (VCA) IgM and anti-EBV VCA IgG. The relationships between HLA alleles, anti-EBV antibody levels, MRI and clinical parameters were assessed in regression analysis. Results The presence of HLA B7 was associated with increased T1-LV and trends indicating increased anti-EBV VCA IgG levels, higher disability (EDSS) and more destructive MRI parameters (increased T2-LV and decreased BPF). The presence of HLA A2 was associated with lower EDSS and a trend toward decreased anti-EBV VCA IgG levels; the associations with MRI variables were not significant. The HLA B7–A2 haplotype was significantly associated with higher T2-LV and T1-LV and a trend toward lower BPF was observed. Conclusions Our data suggest that gene–environment interactions between specific HLA Class I loci and EBV exposure are associated with MRI markers of lesion injury and brain atrophy in MS patients. |
| Databáze: | OpenAIRE |
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