Two new norlignans from the aerial parts of Pouzolzia sanguinea (Blume) Merr
| Autor: | Bui Huu Tai, Phan Van Kiem, Seung Hyun Kim, Nguyen Xuan Nhiem, Nguyen Tuan Anh, Le Thi Hong Nhung, Nguyen Huy Hoang, Pham Thi Mai Huong, Vu Van Doan, Yohan Seo |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Natural Product Research. 36:157-164 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2020.1771707 |
| Popis: | Two new norlignans, pouzolignan N (1) and pouzolignan O (2), together with five known norlignans, pouzolignan F (3), pouzolignan G (4), pouzolignan H (5), pouzolignan L (6), and gnetifolin F (7) were isolated from the aerial parts of Pouzolzia sanguinea (Blume) Merr. Their chemical structures were elucidated via HR-ESI-MS and NMR spectroscopic methods. Absolute configurations at stereocenters were confirmed by comparisons of CD spectra with those of TD-DFT calculations. Compounds 1–6 exhibited chemical structures unique to Pouzolzia species. At a concentration of 30 µM, compounds 1–7 exhibited weak cytotoxic activity toward CAL27 and MDA-MB-231 cell lines (cell viability from 65.3 ± 0.86 to 98.8 ± 1.23%). They also inhibited anoctamin-1 activity with inhibitory rates from 8.1 ± 0.87 to 24.3 ± 1.41%. |
| Databáze: | OpenAIRE |
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