Impact of high-dose oleuropein on cisplatin-induced oxidative stress, genotoxicity and pathological changes in rat stomach and lung

Autor:	Hakan Onalan, Serkan Yildirim, Salim Cerig, Suat Colak, Hatice Isikgoz, Yavuz Selim Saglam, Hüseyin Serkan Erol, Murat Bakir, Mirkhalil Hosseinigouzdagani, Kubra Koc, Fatime Geyikoglu
Rok vydání:	2017
Předmět:	Male 0301 basic medicine Lung Neoplasms Iridoid Glucosides Pharmaceutical Science Pharmacology medicine.disease_cause Antioxidants Analytical Chemistry Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stomach Neoplasms Oleuropein Malondialdehyde Drug Discovery medicine Animals Iridoids Stomach cancer Cisplatin Molecular Structure business.industry Stomach Organic Chemistry Deoxyguanosine General Medicine medicine.disease Rats Oxidative Stress 030104 developmental biology medicine.anatomical_structure Complementary and alternative medicine chemistry 8-Hydroxy-2'-Deoxyguanosine 030220 oncology & carcinogenesis Toxicity Immunology Molecular Medicine business Genotoxicity Oxidative stress DNA Damage medicine.drug
Zdroj:	Journal of Asian Natural Products Research. 19:1214-1231
ISSN:	1477-2213 1028-6020
DOI:	10.1080/10286020.2017.1317751
Popis:	The current systemic treatments of the various solid tumors involve Cisplatin (CIS)-based chemotherapy. Due to its cytotoxicity, this approach is limited. Moreover, the safety of CIS is only discussed especially in breast and stomach cancers. Therefore, we, for the first time, explored the restorative efficacy of oleuropein (OLE), in stomach and lung injuries induced by CIS. Sprague-Dawley rats were divided into eight groups: control CIS, OLE and CIS + OLE. Single dose of (7 mg/kg) CIS was administered intraperitoneally to CIS and CIS + OLE groups. After 24 h, 50, 100 and 200 mg/kg OLE was given for three consecutive days to OLE and CIS + OLE groups. The 8-OH-dG, total oxidative/antioxidant status (TOS/TAS) and malondialdehyde (MDA) levels were evaluated and histopathological analyses were performed on the studied tissues. The results indicated that CIS significantly increased 8-OH-dG, MDA and TOS levels and caused severe tissue damages. However, high dose of OLE induced a significant decrease in the 8-OH-dG, MDA levels, an increase in TAS levels and it restores CIS-induced tissue damages. We hope that the results of this study will provide an impetus for future studies on novel therapeutic strategies including the protective use of oleuropein in gastric and lung cancers due to chemotherapy.
Databáze:	OpenAIRE
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