A Comparison of a Budesonide-Based and a Beclomethasone/Prednisolone-Based Management Strategy for the Treatment of Severe Asthma in General Practice
| Autor: | Kevin A. MacLusky, Govindaraj Mohan, Clifford C. Godley, Pamela L. Todd |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Budesonide
medicine.medical_specialty Beclomethasone Asthma Prednisolone Randomised-controlled-trials Budesonide Antiasthmatics Leadership and Management Severe asthma jel:D Pharmacy jel:C jel:I jel:I1 Internal medicine medicine General Nursing Asthma jel:Z business.industry Health Policy medicine.disease jel:I11 respiratory tract diseases Management strategy Tolerability jel:I18 jel:I19 Anesthesia General practice Prednisolone business medicine.drug |
| Zdroj: | Disease Management and Health Outcomes. 5:83-91 |
| ISSN: | 1173-8790 |
| DOI: | 10.2165/00115677-199905020-00003 |
| Popis: | Objective: Patients with severe asthma often require short courses of oral corticosteroids in addition to their daily inhaled steroid to maintain adequate lung function. The objective of this study was to compare two management strategies for the treatment of severe asthma. A budesonide-based management strategy and a beclomethasone/prednisolone-based management strategy were compared for efficacy and tolerability. Design and Setting: 50 patients were randomised into this 24-week, open, parallel group comparison. Patients received either a budesonide-based treatment strategy (n = 21) - budesonide 800microg twice daily via Turbohaler(R) with 2mg twice daily nebulised budesonide for 7 to 14 days on asthma exacerbation, or a beclomethasone/prednisolone-based treatment strategy (n = 29, 28 evaluable) - beclomethasone 500 to 1000microg twice daily via metered dose inhaler (MDI) plus large volume spacer with 40mg oral prednisolone daily, for 7 to 14 days on asthma exacerbation. Results: Patients receiving the budesonide treatment strategy required fewer courses of rescue steroid during the 24-week study period than patients receiving the beclomethasone/prednisolone treatment strategy (mean 1.7 vs 3.8: p |
| Databáze: | OpenAIRE |
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