Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation
| Autor: | Johanna A. M. Hagenaars, Michiel E. Erasmus, Jan Bollen, Eline M. Bunnik, Imran A Ertugrul, Vincent van Suylen, Massimo A. Mariani |
|---|---|
| Přispěvatelé: | Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Public Health, Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
RD1-811 medicine.medical_treatment Heart preservation 030230 surgery Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Internal medicine Medicine Organ donation Heart transplantation Transplantation Machine perfusion business.industry medicine.anatomical_structure Ventricle Donation Cardiology Heart Transplantation 030211 gastroenterology & hepatology Surgery business Perfusion |
| Zdroj: | Transplantation direct, 7(3):676. LIPPINCOTT WILLIAMS & WILKINS Transplantation Direct Transplantation Direct, Vol 7, Iss 3, p e676 (2021) Transplantation Direct, 7, 3 Transplantation Direct. Wolters Kluwer Health Transplantation Direct, 7 |
| ISSN: | 2373-8731 |
| Popis: | Background. Organ donation after euthanasia is performed in an increasing number of countries. In this donation after circulatory death procedure, it has not been possible to donate the heart. Recent literature, however, reports positive results of heart donation after circulatory death. Therefore, patients who donate organs following euthanasia might be suitable candidates for heart donation. We want to confirm this assumption by sharing the results of 2 cases of heart donation following euthanasia with ex situ subnormothermic heart preservation. Our aim is to raise awareness of the potential of heart donation following euthanasia for both clinical transplantation and research. Methods. The data of 2 consecutive heart donations following euthanasia were collected prospectively. Informed consent was obtained from the patients themselves for heart donation for research purposes. An acellular oxygenated subnormothermic machine perfusion strategy was used to preserve both donor hearts. Subsequently, the hearts were evaluated on a normothermic perfusion machine using a balloon in the left ventricle. Results. Heart donation following euthanasia was feasible without significant changes in existing retrieval protocols. Duration of machine perfusion preservation was 408 and 432 minutes, for heart 1 and 2, respectively. For heart 1, developed pressure (Pdev) was 119 mm Hg, maximal rate of pressure rise (dP/dtmax), and fall (dP/dtmin) were 1524 mm Hg/s and -1057 mm Hg/s, respectively. For heart 2, Pdevwas 142 mm Hg, dP/dtmaxwas 1098 mm Hg/s, and dP/dtminwas -802 mm Hg/s. Conclusions. Hearts donated following euthanasia are highly valuable for research purposes and can have sufficient quality to be transplanted. With the implementation of ex situ heart perfusion, patients who are to donate their organs following euthanasia should also be able to donate their hearts. The complex combination of euthanasia and heart donation is ethically sound and surgically feasible and can contribute to shortening the heart transplant waiting list. |
| Databáze: | OpenAIRE |
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