The Role of Animal Models for Research on Severe Malaria
| Autor: | Craig, A.G., Grau, G.E., Janse, C., Kazura, J.W., Milner, D., Barnwell, J.W., Turner, G., Langhorne, J., Hinxton Retreat Meeting Anim Model |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Erythrocytes
Plasmodium berghei Plasmodium vivax Disease Mice 0302 clinical medicine lcsh:QH301-705.5 0303 health sciences biology 3. Good health qx_20 Cerebral Malaria Plasmodium knowlesi Medicine lcsh:Immunologic diseases. Allergy Primates medicine.medical_specialty Opinion 030231 tropical medicine Immunology Plasmodium falciparum Malaria Cerebral Microbiology 03 medical and health sciences Virology parasitic diseases Genetics medicine Animals Humans Intensive care medicine Molecular Biology Biology 030304 developmental biology Congresses as Topic biology.organism_classification medicine.disease wc_750 Disease Models Animal lcsh:Biology (General) qx_135 Parasitology lcsh:RC581-607 Human Pathology Malaria |
| Zdroj: | PLoS Pathogens, 8(2) PLoS Pathogens PLoS Pathogens, Vol 8, Iss 2, p e1002401 (2012) |
| ISSN: | 1553-7374 |
| Popis: | In light of the recent controversies over the role of animal models for research into the development of new treatments for severe malaria, particularly cerebral disease, a group of scientists came together to discuss the relative merits of a range of animal models and their overlap with the complex clinical syndromes of human disease. While it was not possible to fully resolve differences over the utility of the Plasmodium berghei ANKA model of experimental cerebral malaria, the meeting did bring the two research communities closer together to identify further work to provide information needed to validate the model and revitalise the development of other animal models displaying features of human pathology. The driving force behind this was the desire to ensure better translation of experimental findings into effective treatments for severe malaria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|