Assessment of quality of life and oral function of patients participating in a phase II study of radioprotection of oral and pharyngeal mucosa by the prostaglandin E(1) analog misoprostol (RTOG 96-07)
| Autor: | Darlene J. Johnson, Thomas E Seay, James E. Marks, James A. Wheeler, James N. Atkins, Charles Scott, Lawrence Berk, Raul T Meoz |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Saliva Time Factors medicine.medical_treatment Phases of clinical research Antineoplastic Agents Quality of life Surveys and Questionnaires medicine Ingestion Humans Radiology Nuclear Medicine and imaging Alprostadil Neoplasm Metastasis Misoprostol Laryngeal Neoplasms Aged Radiation Mucous Membrane business.industry Mouth Mucosa Cancer Pharyngeal Neoplasms Middle Aged medicine.disease Surgery Radiation therapy Oncology Toxicity Quality of Life Pharynx Female Mouth Neoplasms business medicine.drug |
| Zdroj: | International journal of radiation oncology, biology, physics. 54(5) |
| ISSN: | 0360-3016 |
| Popis: | Purpose: The oral complications associated with radiotherapy to the head and neck are a significant dose-limiting factor. The goals of this study were to determine whether oropharyngeal rinsing and ingestion of misoprostol protect mucous membranes from the acute effects of irradiation, and to evaluate the quality-of-life (QOL) outcomes of patients receiving misoprostol. We report the results of the QOL outcomes of patients in this study. Methods and Materials: A total of 33 patients with resected or intact cancer of the oral cavity, oropharynx, supraglottic larynx, or hypopharynx were registered to receive postoperative radiotherapy plus misoprostol or primary radiotherapy plus misoprostol. All patients were scheduled to receive 60–70 Gy at 2 Gy/d within 6–7 weeks. QOL and function were evaluated. Results: A decrease in the QOL and function occurred in all areas covered by the questionnaire at the 6-week interval. This decrease was significant for eating, saliva, taste, and mucous. Of these significant factors, taste, saliva, and mucous consistency had not resolved by 12 weeks. Conclusion: Increased understanding of the impact of treatment on QOL and symptoms will formulate the rational design of toxicity interventions and enhance the multidisciplinary care of head-and-neck patients. |
| Databáze: | OpenAIRE |
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