Role of Hsp70 in Cancer Growth and Survival
| Autor: | Sándor Lovas, Marcus P. D. Hatfield |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Molecular Sequence Data Cell Peptide binding Cell Growth Processes Biochemistry Structural Biology Cell Line Tumor Neoplasms medicine Animals Humans HSP70 Heat-Shock Proteins Amino Acid Sequence Chemistry Cancer General Medicine medicine.disease Hsp70 Cell biology Cytosol medicine.anatomical_structure Cyclic nucleotide-binding domain Cancer cell Protein folding Sequence Alignment |
| Zdroj: | Protein & Peptide Letters. 19:616-624 |
| ISSN: | 0929-8665 |
| Popis: | Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|