The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium
| Autor: | Jason Rihel, Robert Gerlai, José G. Ortiz, Soaleha Shams |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal structures Autism Spectrum Disorder Cognitive Neuroscience 03 medical and health sciences Behavioral Neuroscience Broad spectrum 0302 clinical medicine medicine Zebrafish larvae Animals Humans Social Behavior Zebrafish Brain Diseases Behavior Animal biology fungi Human brain medicine.disease biology.organism_classification Disease Models Animal 030104 developmental biology Neuropsychology and Physiological Psychology medicine.anatomical_structure Autism spectrum disorder embryonic structures Autism Psychopharmacology Experimental methods Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 85:176-190 |
| ISSN: | 0149-7634 |
| Popis: | The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders. By providing information on a broad spectrum of brain disorders, experimental methods, and scientific approaches using both larval and adult zebrafish, the review is intended to showcase this underutilized laboratory species for behavioral neuroscience and psychopharmacology research. |
| Databáze: | OpenAIRE |
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