A Comparison of Free and Total 25-hydroxyvitamin D Levels as Functional Indicators of Bone Health in Healthy Children
| Autor: | Yun Jeong Lee, Choong Ho Shin, You Joung Heo, Kyunghoon Lee, Junghan Song, Jae Hyun Kim, Young Ah Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty business.industry Bone and Mineral Metabolism Endocrinology Diabetes and Metabolism Parathyroid hormone Context (language use) Overweight Bone health chemistry.chemical_compound Endocrinology chemistry Internal medicine Vitamin D Diabetes and Energy Metabolism medicine Vitamin D and neurology Free hormone medicine.symptom business Body mass index AcademicSubjects/MED00250 |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/jendso/bvab048.548 |
| Popis: | Abstract Context: The “free hormone” hypothesis suggests that the free 25-hydroxyvitamin D (25OHDFree) level may usefully indicate bone health. Objective: To determine which vitamin D measure is optimally correlated with clinical and bone parameters in healthy children. Design and Participants: A cross-sectional study including 146 healthy children (71 boys, 9.5±1.9 years) at a tertiary medical center. Main Outcome Measures: We used a multiplex liquid chromatography-tandem mass spectrometry-based assay to simultaneously measure vitamin D metabolites. The 25OHDFree level was directly measured (m-25OHDFree) or calculated using genotype-constant or genotype-specific affinity coefficients of vitamin D-binding proteins (con-25OHDFree or spe-25OHDFree). Bone mineral content (BMC) and density (BMD) were assessed via dual-energy X-ray absorptiometry. Results: The concentrations of total 25OHD (25OHDTotal), the three forms of 25OHDFree, and 24,25-dihydroxyvitamin D3 correlated with parathyroid hormone levels (all p factors. In normal-weight children, the con-25OHDFree level reflected BMC and BMD, whereas the 25OHDTotal level was associated with BMC. |
| Databáze: | OpenAIRE |
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