Sub-micrometer axial resolution OCT for in-vivo imaging of the cellular structure of healthy and keratoconic human corneas
| Autor: | Kostadinka Bizheva, Benjamin MacLelan, Mojtaba Hajialamdari, Olivera Kralj, Bingyao Tan, Luigina Sorbara, Denise Hileeto |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Keratoconus Visual acuity genetic structures Lateral resolution 01 natural sciences Article 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology 0103 physical sciences medicine Medical imaging Corneal epithelium medicine.diagnostic_test business.industry Corneal Diseases medicine.disease eye diseases Atomic and Molecular Physics and Optics 3. Good health medicine.anatomical_structure 030221 ophthalmology & optometry sense organs medicine.symptom business Preclinical imaging Biotechnology |
| Zdroj: | Biomedical Optics Express. 8:800 |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.8.000800 |
| Popis: | Corneal degenerative conditions such as keratoconus (KC) cause progressive damage to the anterior corneal tissue and eventually severely compromise visual acuity. The ability to visualize corneal tissue damage in-vivo at cellular or sub-cellular level at different stages of development of KC and other corneal diseases, can aid the early diagnostics as well as the development of more effective treatment approaches for various corneal pathologies, including keratoconus. Here, we present the optical design of an optical coherence tomography system that can achieve 0.95 µm axial resolution in biological tissue and provide test results for the system’s spatial resolution and sensitivity. Corneal images acquired in-vivo with this system from healthy and keratoconic human subjects reveal the cellular and sub-cellular structure of the corneal epithelium, as well as the normal and abnormal structure of the Bowman’s membrane and the anterior corneal stroma. |
| Databáze: | OpenAIRE |
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