Randomised clinical study comparing the effectiveness and physiological effects of hypertonic and isotonic polyethylene glycol solutions for bowel cleansing
| Autor: | Kentarou Satou, Hiro-o Matsushita, Yasushi Imai, Ryogo Himori, Eiji Harada, Ryo Takagi, Michiko Nakaoka, Kenjiro Yoshikawa, Yuko Yoshida, Hiro-o Yamano, Yoshihito Tanaka |
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| Rok vydání: | 2016 |
| Předmět: |
COLONOSCOPY
ENDOSCOPY Colon Nausea Colonoscopy macromolecular substances 03 medical and health sciences 0302 clinical medicine PEG ratio Medicine Dehydration Dosing Adverse effect medicine.diagnostic_test business.industry technology industry and agriculture Gastroenterology medicine.disease Regimen 030220 oncology & carcinogenesis Anesthesia ENDOSCOPIC PROCEDURES Tonicity 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | BMJ Open Gastroenterology |
| ISSN: | 2054-4774 |
| DOI: | 10.1136/bmjgast-2016-000101 |
| Popis: | Objectives Bowel cleansing is necessary before colonoscopy, but is a burden to patients because of the long cleansing time and large dose volume. A low-volume (2 L) hypertonic polyethylene glycol-ascorbic acid solution (PEG-Asc) has been introduced, but its possible dehydration effects have not been quantitatively studied. We compared the efficacy and safety including the dehydration risk between hypertonic PEG-Asc and isotonic PEG regimens. Design This was an observer-blinded randomised study. Participants (n=310) were allocated to receive 1 of 3 regimens on the day of colonoscopy: PEG-Asc (1.5 L) and water (0.75 L) dosed with 1 split (PEG-Asc-S) or 4 splits (PEG-Asc-M), or PEG-electrolyte solution (PEG-ES; 2.25 L) dosed with no split. Dehydration was analysed by measuring haematocrit (Ht). Results The cleansing time using the hypertonic PEG-Asc-S (3.33±0.48 hours) was significantly longer than that with isotonic PEG-ES (3.05±0.56 hours; p |
| Databáze: | OpenAIRE |
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