Development of risk factor-based scoring system for detection of hypervirulent Klebsiella pneumoniae bloodstream infections
| Autor: | Yasushi Takamatsu, Akira Matsunaga, Atsushi Togawa, Chiemi Tokushige, Michinobu Yoshimura, Tohru Takata |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Serotype medicine.medical_specialty Scoring system Klebsiella pneumoniae 030106 microbiology Capsular serotype Bloodstream infection Microbiology 03 medical and health sciences Medical microbiology Virology Internal medicine medicine Hypermucoviscosity Risk factor lcsh:RC799-869 biology business.industry Research Gastroenterology Hypervirulent Klebsiella pneumoniae Retrospective cohort study biology.organism_classification medicine.disease 030104 developmental biology Infectious Diseases Parasitology lcsh:Diseases of the digestive system. Gastroenterology business Liver abscess |
| Zdroj: | Gut Pathogens Gut Pathogens, Vol 12, Iss 1, Pp 1-7 (2020) |
| ISSN: | 1757-4749 |
| Popis: | Background Hypervirulent Klebsiella pneumoniae (HVKp) infections have distinct clinical manifestations from classical K. pneumoniae infections. The hallmark of HVKp infections are liver abscess formation and metastatic infections. Due to the severe sequelae of these complications, method to identify patients at-risk of HVKp infections should be developed. Results A retrospective cohort study of 222 patients with K. pneumoniae bloodstream infections (BSIs) was performed. Patient demographics, clinical manifestations, and bacterial characteristics were investigated. Ten cases of liver abscesses were identified. Characteristics such as community-onset BSIs, hypermucoviscosity phenotype, and capsular serotype K1 were identified as risk factors for HVKp infections. A scoring system was developed based on the risk factors. The area under the receiver operating characteristic curve for the scoring system was 0.90. A score of ≥ 2 points provided sensitivity and specificity of 0.70 and 0.94, respectively. Conclusions Simple scoring system was developed for the diagnosis of HVKp infections. The system allows early identification of patients with K. pneumoniae BSIs in whom hypervirulent infections should be evaluated. Prospective evaluation is expected. |
| Databáze: | OpenAIRE |
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