Effect of peripherally-injected glucagon-like peptide-1 on gastric mucosal blood flow

Autor: Naciye Isbil-Buyukcoskun, Betul Cam-Etoz, Kasim Ozluk, Guldal Gulec
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., İşbil, Naciye Büyükcoşkun, Çam, Betül Etöz, Suyen, Güldal Güleç, Özlük, Kasım, C-5730-2015, AAH-1692-2021
Jazyk: angličtina
Rok vydání: 2009
Předmět:
System
Amide
Male
Physiology
Rats
sprague-dawley
Clinical Biochemistry
Indomethacin
Gene-related peptide
Glucagon like peptide 1
Biochemistry
Stomach mucosa blood flow
chemistry.chemical_compound
Laser Doppler flowmetry
Endocrinology
Mechanisms
Endocrinology & metabolism
Priority journal
biology
Prostaglandin derivative
Stomach
digestive
oral
and skin physiology
Glucagon-like peptide-1
Injections
intraperitoneal
medicine.anatomical_structure
Gastrointestinal hormone
Experimental-models
Calcitonin gene-related peptide
CGRP-(8-37)
Somatostatin
Alcohol
Drug mechanism
medicine.drug
medicine.medical_specialty
N(g) nitroarginine methyl ester
Gastric Mucosa
Vanilloid Receptor 1
Article
Nitric oxide
Glp-1
Cellular and Molecular Neuroscience
Indometacin
L-NAME
Calcitonin gene related peptide[8-37]
Internal medicine
medicine
Gastric mucosa
Animals
Peptide fragments
Animal experiment
Glucagon-like peptide 1
Ethanol
Nitric oxide synthase
Time factors
Nonhuman
Rats
Stomach protection
Drug effect
Gastric mucosal blood flow
Outcome assessment
chemistry
biology.protein
Rat
Regional blood flow
Cyclooxygenase
Involvement
Calcitonin gene related peptide
Controlled study
Popis: The aim of this study was to investigate the mechanisms involved in the effect of glucagon-like peptide-1 (GLP-1) on the decrease in gastric mucosal blood flow (GMBF) induced by intragastric ethanol. After preparation of the stomach for GMBF recording, a probe was placed to the gastric mucosa and basal GMBF recordings were obtained by a laser Doppler flowmeter after a 30-minute stabilization period. Following GLP-1 (1000 ng/kg; i.p.) injection, 1 ml of absolute ethanol was applied to the gastric chamber and GMBF was recorded continuously during a 30-minute period. GLP-1 (1000 ng/kg; i.p.) prevented the decrease in GMBF induced by ethanol. Nitric oxide (NO) synthase inhibitor L-NAME, (30 mg/kg; s.c.), calcitonine gene-related peptide (CGRP) receptor antagonist CGRP-(8–37) (10μg/kg; i.p.), and cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.) all inhibited the GMBF-improving effect of GLP-1. We concluded that, NO, CGRP and prostaglandins may be involved in the effect of peripherally-injected GLP-1 on GMBF reduction induced by intraluminal ethanol.
Databáze: OpenAIRE
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