Changes in Plasma Bioactive Lipids and Inflammatory Markers during a Half-Marathon in Trained Athletes

Autor: Amalia Gastaldelli, Melania Gaggini, Francesca Mastorci, Maristella Maltinti, Francesco Sbrana, Cristina Vassalle, Fabrizia Carli, Alessandro Pingitore, Emma Buzzigoli, Laura Sabatino
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
medicine.medical_specialty
Ceramide
Technology
QH301-705.5
QC1-999
Inflammation
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Aerobic exercise
General Materials Science
Biology (General)
CX3CL1
Instrumentation
QD1-999
Diacylglycerol kinase
Fluid Flow and Transfer Processes
ceramides
biology
medicine.diagnostic_test
exercise
diacylglycerol
business.industry
Athletes
Process Chemistry and Technology
Physics
General Engineering
biomarkers
biology.organism_classification
Engineering (General). Civil engineering (General)
cytokines
Computer Science Applications
Chemistry
030104 developmental biology
Endocrinology
chemistry
Tumor necrosis factor alpha
lipids (amino acids
peptides
and proteins)
medicine.symptom
TA1-2040
business
Lipid profile
Zdroj: Applied Sciences, Vol 11, Iss 4622, p 4622 (2021)
Applied Sciences
Volume 11
Issue 10
ISSN: 2076-3417
Popis: Background: Exercise may affect lipid profile which in turn is related to inflammation, although changes of ceramides, diacylglycerols-DAG and sphingomyelin-SM and their relationship with inflammatory parameters following a half-marathon have never been examined. Methods: Ceramides, DAG and SM, and markers of inflammation (soluble fractalkine-CX3CL1, vascular endothelial growth factor-VEGF, interleukin6-IL-6 and tumor necrosis factorα-TNFα) were evaluated in trained half-marathoners before, post-race (withdrawal within 20 min after the race end) and 24 h after. Results: IL-6 and CX3CL1 increased immediately after the race, returning to baseline after 24 h. Total ceramides and total DAG significantly decreased post-race. Several ceramide classes decreased after exercise, while only one of the DAG (36:3) changed significantly. Total SM and specific species did not significantly change. Conclusion: Some inflammatory parameters (IL-6 and CX3CL1) transiently increased after the race, and, being reversible, these changes might represent a physiological response to acute exercise rather than a damage-related response. The decrease of specific lipid classes, i.e., DAGs and ceramides, and the lack of their relationship with inflammatory parameters, suggest their involvement in beneficial training effects, opening promising research perspectives to identify additional mechanisms of aerobic exercise adaptation.
Databáze: OpenAIRE
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