Pancuronium increases pulmonary arterial pressure in lung injury
| Autor: | K. Suwa, Kazuo Hanaoka, Anthony P. Adams, Nobuhide Kin, Yoshitsugu Yamada, R. Orii, M. Hayashita, H L Du |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Blood Pressure Pulmonary Edema Pulmonary arterial pressure Pulmonary Artery Lung injury Hypoxemia Dogs Internal medicine medicine Animals Pancuronium Cardiac Output Pulmonary wedge pressure Phentolamine Lung biology business.industry Fissipedia Respiratory disease Vagus Nerve respiratory system biology.organism_classification medicine.disease respiratory tract diseases Anesthesiology and Pain Medicine Blood pressure medicine.anatomical_structure Anesthesia Cardiology Vascular resistance Female Vascular Resistance medicine.symptom business Neuromuscular Nondepolarizing Agents Oleic Acid |
| Zdroj: | British Journal of Anaesthesia. 77:526-529 |
| ISSN: | 0007-0912 |
| Popis: | We studied 25 mongrel dogs who were anaesthetized and their lungs ventilated for investigation of the effects of pancuronium on pulmonary arterial pressure (PAP) in the normal lung, in oleic acid-induced lung injury and in lung injury with hypoxaemia. In the normal lung, PAP was not affected by pancuronium. During lung injury, however, PAP was increased from 21.5 (SD 2.8) to 24.6 (4.2) mm Hg (P0.01) and from 22.0 (4.2) to 27.0 (5.8) mm Hg (P0.01) after pancuronium 0.08 mg kg-1 and 0.16 mg kg-1, respectively, and from 26.0 (2.9) to 37.1 (3.1) mm Hg after pancuronium 0.16 mg kg-1 when hypoxaemia was present (P0.01). The increase in PAP induced by pancuronium was associated with increases in cardiac output and pulmonary vascular resistance. Pretreatment with phentolamine attenuated the pancuronium-induced increase in PAP. The increase in PAP induced by pancuronium was also reduced by vagotomy. If these results in dogs are relevant clinically, then pancuronium should be avoided as a neuromuscular blocker in lung injury. |
| Databáze: | OpenAIRE |
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