Vitamin E and lipid peroxide plasma levels predict the risk of cardiovascular events in a group of healthy very old people
| Autor: | Andrea Mezzetti, Giovanni Zuliani, Ferdinando Romano, Fabrizio Costantini, Sante D. Pierdomenico, Franco Cuccurullo, Renato Fellin, null The Associazione Medica Sabin |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Male
Lipid Peroxides Longitudinal study medicine.medical_specialty medicine.medical_treatment Lipid peroxidation Myocardial Infarction Blood lipids Ascorbic Acid Age Distribution Predictive Value of Tests Risk Factors Internal medicine medicine Humans Vitamin E Longitudinal Studies Total cholesterol Triglycerides Aged Aged 80 and over Heart Failure Vitamin C Lipid peroxide business.industry Incidence Cholesterol HDL Age Factors Cholesterol LDL Cardiovascular risk Confidence interval Stroke Oxidative Stress Older Cholesterol Endocrinology Italy Quartile Relative risk Multivariate Analysis Female Geriatrics and Gerontology business |
| Popis: | OBJECTIVES: To assess whether systemic oxidative stress can predict the risk of first myocardial infarction, ischemic stroke, and congestive heart failure. DESIGN: A longitudinal study started in 1992 and completed in 1997. SETTING: Community-based, outpatient. PARTICIPANTS: 102 apparently healthy, community-dwelling subjects age 80 and older from the Vibrata valley, Teramo, Italy. MEASUREMENTS: Plasma vitamin E, β-carotene, vitamin C, fluorescent products of lipid peroxidation (FPLPs), and serum lipids were determined at enrollment. RESULTS: Thirty-two cardiovascular events were recorded in 47.4 months of follow-up. The subjects with vitamin E levels in the highest quartile had a risk of cardiovascular events one-sixth those with vitamin E levels in the lowest quartile (relative risk (RR) = 0.16; 95% confidence interval (CI) = 0.04–0.55). The subjects with FPLPs in the highest quartile had a risk seven times greater than those with FPLPs in the lowest quartile (RR = 7.61; 95% CI = 2.23–25.96). No association was observed for vitamin C, β-carotene, or total cholesterol. Multivariate adjustment for known risk factors did not significantly change the results. CONCLUSIONS: Our results suggest that in apparently healthy, community-dwelling very old subjects, base-line plasma concentration of vitamin E and FPLPs predicts the risk of future cardiovascular events. We confirm previous data showing that total cholesterol is not a predictor of cardiovascular disease in people age 80 and older. |
| Databáze: | OpenAIRE |
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