Tissue-Specific Phenotype and Activation of iNKT Cells in Morbidly Obese Subjects: Interaction with Adipocytes and Effect of Bariatric Surgery
| Autor: | Alberto Rodríguez-Cañete, Sergio Valdés, Marta Cejudo-Guillén, Lourdes Garrido-Sánchez, Ailec Ho-Plagaro, Gonzalo Alba, Francisca Rodriguez-Pacheco, Soledad Lopez, David Pozo, Concepcion Santiago-Fernandez, Eduardo García-Fuentes, Carolina Gutiérrez-Repiso, Sara García-Serrano |
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| Přispěvatelé: | Instituto de Salud Carlos III, Junta de Andalucía, European Commission, García-Fuentes, Eduardo, García-Fuentes, Eduardo [0000-0002-3491-2724] |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue Bariatric Surgery chemical and pharmacologic phenomena Inflammation Intra-Abdominal Fat 03 medical and health sciences Insulin resistance Immune system Internal medicine parasitic diseases medicine Adipocytes Humans Obesity IL-2 receptor Nutrition and Dietetics biology business.industry Insulin nutritional and metabolic diseases hemic and immune systems medicine.disease Natural killer T cell Obesity Morbid 030104 developmental biology Endocrinology Phenotype CD1D biology.protein Natural killer T cells Natural Killer T-Cells Surgery medicine.symptom business human activities |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1708-0428 |
| Popis: | [Background]] The immune response of visceral adipose tissue (VAT) in obesity, in particular the role of invariant natural killer T (iNKT) cells, has not yet been fully elucidated. [Objective] To characterize iNKT cells and its activation status in VAT and peripheral blood mononuclear cells (PBMC) in morbidly obese subjects (MO), and to analyze their association with metabolic parameters. [Subjects and Methods] Twenty non-obese and 20 MO subjects underwent Roux-en-Y gastric bypass (RYGB) and were studied before and 6 months after RYGB. VAT and PBMC were obtained. [Results] A decrease in VAT iNKT cells from MO was found, however, not in PBMC. Visceral adipocytes from MO presented increased CD1d expression (p = 0.032). MO presented an increase in early activated CD69+ iNKT cells in PBMC before RYGB (p [Conclusions] There is a tissue-specific phenotype and activation of iNKT cells in VAT in morbid obesity, which could be involved in VAT immunometabolism dysregulation. Also, the increase in CD1d expression could be to offset the lack of VAT iNKT cells. This study has been supported by the Instituto de Salud Carlos III (ISCIII) (PI09/01016) (BA way to make Europe^), the Andalusian Ministry of Health (PI-2013-575), and the Andalusian Ministry of Economy, Science and Innovation (P10-CTS6928, P11-CTS8161 and P11-CTS8081) and co-financed by the European Regional Development Fund (FEDER) (BAndalusia moves with Europe^). |
| Databáze: | OpenAIRE |
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