IMGT® databases, related tools and web resources through three main axes of research and development

Autor: Taciana Manso, Géraldine Folch, Véronique Giudicelli, Joumana Jabado-Michaloud, Anjana Kushwaha, Viviane Nguefack Ngoune, Maria Georga, Ariadni Papadaki, Chahrazed Debbagh, Perrine Pégorier, Morgane Bertignac, Saida Hadi-Saljoqi, Imène Chentli, Karima Cherouali, Safa Aouinti, Amar El Hamwi, Alexandre Albani, Merouane Elazami Elhassani, Benjamin Viart, Agathe Goret, Anna Tran, Gaoussou Sanou, Maël Rollin, Patrice Duroux, Sofia Kossida
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nucleic Acids Research
ISSN: 1362-4962
0305-1048
Popis: IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org/, is at the forefront of the immunogenetics and immunoinformatics fields with more than 30 years of experience. IMGT® makes available databases and tools to the scientific community pertaining to the adaptive immune response, based on the IMGT-ONTOLOGY. We focus on the recent features of the IMGT® databases, tools, reference directories and web resources, within the three main axes of IMGT® research and development. Axis I consists in understanding the adaptive immune response, by deciphering the identification and characterization of the immunoglobulin (IG) and T cell receptor (TR) genes in jawed vertebrates. It is the starting point of the two other axes, namely the analysis and exploration of the expressed IG and TR repertoires based on comparison with IMGT reference directories in normal and pathological situations (Axis II) and the analysis of amino acid changes and functions of 2D and 3D structures of antibody and TR engineering (Axis III).
Databáze: OpenAIRE