The effects on toxicity of circadian patterning of continuous hepatic artery infusion
| Autor: | M. Margaret Kemeny, Fred B. Smith, Galo Alava, Jorge M. Oliver |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Continuous infusion
Cholangitis Sclerosing lcsh:Surgery Drug Administration Schedule Hepatic Artery Floxuridine Medicine Animals Infusions Intra-Arterial Circadian rhythm lcsh:RC799-869 Survival rate Chronobiology Hepatology business.industry Rats Inbred Strains lcsh:RD1-811 Rats Inbred F344 Circadian Rhythm Rats Survival Rate Artery infusion Liver Anesthesia Toxicity Maximum dose lcsh:Diseases of the digestive system. Gastroenterology Surgery business medicine.drug Research Article |
| Zdroj: | HPB Surgery HPB Surgery, Vol 5, Iss 3, Pp 185-194 (1992) |
| ISSN: | 0894-8569 |
| Popis: | Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who received a constant infusion schedule of 15mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was given during the hours of 3pm to 9pm then all of the animals survived the 14 day infusion. If the maximum dose of infusion was changed so that 60% of the infusion was given at night from 3am to 9am the infusion became more toxic and all the animals died in a mean of 5.5 days. Pathologic sectioning of all the livers reflected the above outcomes with the greatest amount of hepatic necrosis in the animals on the night cycles. This study underscores the recent advances in chronobiology demonstrating that for continuous hepatic arterial infusions the timing of delivery is crucial in determining the toxicity. |
| Databáze: | OpenAIRE |
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