Antifouling silicone hydrogel contact lenses via densely grafted phosphorylcholine polymers
| Autor: | Alysha Spadafora, Heather Sheardown, Myrto Korogiannaki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Plasma Gases
Biofouling Polymers Surface Properties Phosphorylcholine Silicones General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Biomaterials Contact angle Oxygen permeability Animals General Materials Science chemistry.chemical_classification Chemistry Atom-transfer radical-polymerization Hydrogels Serum Albumin Bovine General Chemistry Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Contact lens Chemical engineering Wettability Surface modification Methacrylates Cattle Muramidase Wetting Adsorption 0210 nano-technology Protein adsorption |
| Zdroj: | Biointerphases. 15(4) |
| ISSN: | 1559-4106 |
| Popis: | Silicone hydrogel contact lenses (CLs) permit increased oxygen permeability through their incorporation of siloxane functional groups. However, contact lens biofouling can be problematic with these materials; surface modification to increase lens compatibility is necessary for acceptable properties. This work focuses on the creation of an antifouling CL surface through a novel grafting method. A polymer incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC), well known for its antifouling and biomimetic properties, was grafted to the model lens surfaces using surface-initiated atom transfer radical polymerization (SI-ATRP). The SI-ATRP modification generated a unique double-grafted polymeric architecture designed to resist protein adsorption through the presence of a surrounding hydration layer due to the PC groups and steric repulsion due to the density of the grafted chains. The polymer was grafted from model silicone hydrogel CL using a four-step SI-ATRP process. Attenuated total reflectance-Fourier transform infrared spectroscopy and XPS were used to confirm the surface chemical composition at each step of the synthesis. Both the surface wettability and equilibrium water content of the materials increased significantly upon polyMPC modification. The surface water contact angle was as low as 16.04 ± 2.37° for polyMPC-50 surfaces; complete wetting (∼0°) was observed for polyMPC-100 surfaces. A decrease in the protein adsorption by as much as 83% (p |
| Databáze: | OpenAIRE |
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