Experimental evaluation of Hiṅgvādi Ghṛta in behavioral despair using animal models
| Autor: | Asmita Wele, Poonam Ashish Gupte, Jayshree Shriram Dawane |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Diminution
business.industry lcsh:R ghee lcsh:Medicine Context (language use) General Medicine Anxiety Pharmacology 030226 pharmacology & pharmacy neurotransmitters Tail suspension test One-way analysis of variance 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Antidepressant Medicine psychosis unmad Imipramine Hydrochloride business Student's t-test Behavioural despair test |
| Zdroj: | Ancient Science of Life, Vol 36, Iss 2, Pp 84-89 (2016) |
| ISSN: | 0257-7941 |
| DOI: | 10.4103/asl.asl_78_16 |
| Popis: | Context: Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurveda for leads. Aim: To evaluate Anti- depressant activity of Hiṅgvādi Ghṛta in vivo. Settings and Design: Comparative preclinical study. Materials and Methods: Hiṅgvādi Ghṛta (HG) was prepared using standard operating procedure, physicochemically analyzed and assessed. Tail Suspension Test (TST) model with Swiss albino mice and Forced Swim Test (FST) model with Wistar albino rats were used to assess anti-depressant activity. Imipramine hydrochloride in dose of 15 mg/kg for TST and 10 mg/kg for FST, was the standard drug and Ghee as vehicle control in dose of 0.1g/20g for TST and 0.72g/200g for FST orally. Hiṅgvādi Ghṛta in doses of 0.05g/20g (x/2), 0.1g/20g (x) and 0.2 g/20g (2x) for TST and 0.36g/200g (x/2), 0.72g/200g (x) and 1.44g/200g (2x) for FST was administered to 3 test groups for 21 days orally except Plain control group which received only distilled water. Duration of immobility in seconds for TST and number of rotations for FST were noted for assessment. Statistical Analysis Used: One way ANOVA followed by Dunnets test and Paired t test. Results: HG was significantly effective at dose of 0.1gm/20gm for TST (P = 0.0037; P < 0.01) and 0.72g/200g for FST (P = 0.0055, P < 0.01) comparable to Imipramine hydrochloride. Conclusions: HG displayed potent anti depressant activity comparable to standard drug Imipramine Hydrochloride. |
| Databáze: | OpenAIRE |
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