The influence of pimozide, haloperidol, α-methyl-p-tyrosine and reserpine on the development of morphine dependence in rats
| Autor: | Romuald Langwiński, Alicja Kruszewska |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Reserpine Methyltyrosines Toxicology Serotonergic Synaptic Transmission 5-Hydroxytryptophan chemistry.chemical_compound Catecholamines Pimozide Internal medicine medicine Haloperidol Animals Humans Pharmacology (medical) Tyrosine Neurotransmitter Pharmacology Catecholaminergic Chemistry Morphine dependence Rats Inbred Strains Rats Psychiatry and Mental health alpha-Methyltyrosine Endocrinology Morphine Dependence medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 11:383-388 |
| ISSN: | 0376-8716 |
| Popis: | It was found that pimozide, haloperidol and α -methyl- p -tyrosine (α-MT), drugs inhibiting central catecholaminergic (CA) transmission, increased the development of morphine dependence measured as wet dog shakes in rats. Reserpine inhibiting CA and serotoninergic (5-HT) transmission, decreased the development of morphine dependence in rats. The inhibitory effect of reserpine was reversed by 5-hydroxytryptophan (5-HTP), but not by L-dihydroxyphenylalanine (L-DOPA). These results suggest that wet dog shakes might develop as a result of regulatory adaptation in the 5-HT neurotransmitter system. |
| Databáze: | OpenAIRE |
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