Procyanidins protects against oxidative damage and cognitive deficits after traumatic brain injury
| Autor: | Hao Zhang, Feifan Xu, Xiang Mao, Baiyun Liu, Weichuan Wu, Zhendan Zhu, Shuyu Hao |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Traumatic brain injury Neuroscience (miscellaneous) Hippocampus Principal factor medicine.disease_cause CREB Antioxidants Oxidative damage Rats Sprague-Dawley Random Allocation Malondialdehyde Developmental and Educational Psychology medicine Animals Proanthocyanidins Cyclic AMP Response Element-Binding Protein Maze Learning Neuronal Plasticity biology Superoxide Dismutase Brain-Derived Neurotrophic Factor Cognition medicine.disease Glutathione ANT Rats Oxidative Stress nervous system Brain Injuries biology.protein Neurology (clinical) Psychology Cognition Disorders Neuroscience Oxidative stress |
| Zdroj: | Brain injury. 29(1) |
| ISSN: | 1362-301X |
| Popis: | Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates the events that result in protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect the brain against oxidative damage and modulate the capacity of the brain to cope with synaptic dysfunction and cognitive impairment.To date, however, no studies have investigated the effects of procyanidins (PC) on cognitive deficits after TBI.In the present study, rats with controlled cortical impact (CCI) were used to investigate the protective effects of procyanidins.The results showed that procyanidins reduced the level of malondialdehyde (MDA) and elevated the level of glutathione (GSH) and the activity of superoxide dismutase (SOD). In addition, treatment with procyanidins, which elevated the levels of brain-derived neurotropic factor (BDNF), phosphorylation-cAMP-response element binding protein (pCREB), total CREB, and cyclic AMP (cAMP), improved cognitive performance in the Morris water maze after TBI.These results suggest that procyanidins appear to counteract oxidative damage and behavioral dysfunction after TBI through antioxidant activity and the up-regulation of cAMP/CREB signaling. |
| Databáze: | OpenAIRE |
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