Serum levels of per- and polyfluoroalkyl substances alternatives and blood pressure by sex status: Isomers of C8 health project in China

Autor: Hong Yao Yu, Yang Zhou, Xiao Wen Zeng, Xin Mi, Ru Qing Liu, Bo-Yi Yang, Yun Qing Yang, Guang-Hui Dong, Mohammed Zeeshan, Zhibin Wang, Li-Wen Hu, Xiao Yun Zeng
Rok vydání: 2020
Předmět:
Adult
China
Environmental Engineering
Halogenation
Health
Toxicology and Mutagenesis
0208 environmental biotechnology
Physiology
Blood Pressure
Pilot Projects
02 engineering and technology
010501 environmental sciences
01 natural sciences
Ether
Elevated blood
chemistry.chemical_compound
Sex Factors
Isomerism
Environmental Chemistry
Medicine
Humans
0105 earth and related environmental sciences
Aged
Aged
80 and over
Fluorocarbons
business.industry
Public Health
Environmental and Occupational Health
General Medicine
General Chemistry
Odds ratio
Environmental Exposure
Serum concentration
Middle Aged
Pollution
020801 environmental engineering
Blood pressure
chemistry
Alkanesulfonic Acids
Toxicity
Hypertension
Perfluorooctanoic acid
Environmental Pollutants
Female
Caprylates
Sulfonic Acids
business
Ethers
Zdroj: Chemosphere. 261
ISSN: 1879-1298
Popis: Several in vitro and in vivo studies have demonstrated the toxicity of perfluoroalkyl and polyfluoroalkyl substances (PFASs) alternatives, however, relevant epidemiological findings remain to be performed. In addition, the association between PFASs alternatives and blood pressure has not been explored. To address this gap, we quantified serum levels of alternatives and legacy PFAS in 1273 healthy Chinese, aged 34–94 years, from “isomers of C8 health project”. Our results showed that an increase of serum PFASs levels was correlated with elevated blood pressure and higher prevalence of hypertension: per natural log unit (ng/mL) increase of 6:2 chlorinated polyfluorinated ether sulfonic acids (Cl-PFESA) elevated 1.31 (95%CI: 0.13, 2.50) mmHg of diastolic pressure (DBP). Adjusted odds ratios (aORs) for hypertension with per natural log increase of 6:2 and 8:2 Cl-PFESA were 2.57 (95%CI: 1.86, 3.56) and 1.18 (95%CI: 1.06, 1.32), respectively. When stratified by sex, the effects of PFASs alternatives on increased blood pressure and hypertension were stronger in women. Meanwhile, the association between 6:2 Cl-PFESA (aOR = 6.81; 95%CI: 3.54, 13.09) and hypertension was stronger than perfluorooctanoic acid (PFOA) (aOR = 2.32, 95%CI: 1.38, 3.91) in women. In conclusion, our pilot study demonstrates that serum concentrations of PFASs alternatives are positively associated with blood pressure. Moreover, women seem to be more susceptible, and alternatives exhibited stronger effects than legacy PFASs.
Databáze: OpenAIRE
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