Sestrin family - the stem controlling healthy ageing
| Autor: | Andrei V. Budanov, Alexander Haidurov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Programmed cell death Aging Sestrins Stem Cells Autophagy mTORC1 Biology Mitochondrion mTORC2 Antioxidants Cell biology 03 medical and health sciences Oxidative Stress 030104 developmental biology 0302 clinical medicine Ageing Animals Humans Viability assay Stem cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Mechanisms of ageing and development. 192 |
| ISSN: | 1872-6216 |
| Popis: | Sestrins are a family of stress-responsive antioxidant proteins responsible for regulation of cell viability and metabolism. The best known Sestrin targets are mTORC1 and mTORC2 kinases that control different cellular processes including growth, viability, autophagy, and mitochondrial metabolism. Inactivation of the single Sestrin gene in invertebrates has an adverse impact on their healthspan and longevity, whereas each of the three Sestrin genes in mammals and other vertebrate organisms has a different impact on maintenance of a particular tissue, affecting its stress tolerance, function and regenerative capability. As a result, Sestrins attenuate ageing and suppress development of many age-related diseases including myocardial infarction, muscle atrophy, diabetes, and immune dysfunction, but exacerbate development of chronic obstructive pulmonary disease. Moreover, Sestrins play opposite roles in carcinogenesis in different tissues. Stem cells support tissue remodelling that influences ageing, and Sestrins might suppress ageing and age-related pathologies through control of stem cell biology. In this review, we will discuss the potential link between Sestrins, stem cells, and ageing. |
| Databáze: | OpenAIRE |
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