Assessment of Cytosine Arabinoside as an Antiviral Agent in Humans
| Autor: | Lerner Am, Bailey Ej, Carl B. Lauter |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Dose
Herpesvirus 2 Human Herpesvirus 1 Human Microbial Sensitivity Tests Biology Antiviral Agents Cell Line chemistry.chemical_compound Pharmacokinetics Chlorocebus aethiops medicine Animals Humans Pharmacology (medical) Cytotoxicity Vero Cells Pharmacology Idoxuridine Cytarabine Temperature Articles In vitro carbohydrates (lipids) Clinical trial Infectious Diseases chemistry Immunology Vero cell Cytosine medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 6:598-602 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.6.5.598 |
| Popis: | Cytotoxicity, minimal inhibitory concentrations of herpesviruses, and pharmacokinetic studies of cytosine arabinoside (ara-C) were done. Ara-C compared favorably with idoxuridine in in vitro studies of antiviral activity versus herpes simplex, varicella-zoster, and cytomegalovirus. However, ara-C was 10 times more toxic to tissue cultures, and concentrations in serum and urine of three patients who were given ara-C at acceptable dosages (1 mg/kg per day) were not measurable by our assay. These studies predict that ara-C is not likely to be a useful antiviral agent in humans because its therapeutic to toxic ratio approaches unity. These predictions of little clinical efficacy seem now to have been confirmed by clinical trails in humans. Pharmacokinetic studies outlined here should precede and help formulate controlled clinical trials of potential antiviral agents in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|