Differential fuel utilization in liver transplant recipients and its relationship with non‐alcoholic fatty liver disease

Autor:	Mohammad S. Siddiqui, Samarth Patel, Mikael Forsgren, Anh T. Bui, Steve Shen, Taseen Syed, Sherry Boyett, Shanshan Chen, Arun J. Sanyal, Susan Wolver, Danielle Kirkman, Francesco S. Celi, Chandra S. Bhati
Rok vydání:	2022
Předmět:	Liver Cirrhosis Chronic Liver Disease and Cirrhosis Clinical Sciences carbohydrates Carbohydrates Gastroenterology and Hepatology fatty acids Oral and gastrointestinal Hepatitis metabolic flexibility Non-alcoholic Fatty Liver Disease energy expenditure Gastroenterologi Humans Obesity Metabolic and endocrine Nutrition Transplantation liver transplantation Gastroenterology & Hepatology Hepatology Liver Disease Prevention Liver Transplantation non-alcoholic steatohepatitis Digestive Diseases
Zdroj:	Liver international : official journal of the International Association for the Study of the Liver, vol 42, iss 6
ISSN:	1478-3231 1478-3223
DOI:	10.1111/liv.15178
Popis:	Metabolic flexibility is the ability to match biofuel availability to utilization. Reduced metabolic flexibility, or lower fatty acid (FA) oxidation in the fasted state, is associated with obesity. The present study evaluated metabolic flexibility after liver transplantation (LT). Methods Patients receiving LT for non-alcoholic steatohepatitis (NASH) (n = 35) and non-NASH (n = 10) were enrolled. NASH was chosen as these patients are at the highest risk of metabolic complications. Metabolic flexibility was measured using whole-body calorimetry and expressed as respiratory quotient (RQ), which ranges from 0.7 (pure FA oxidation) to 1.0 is (carbohydrate oxidation). Results The two cohorts were similar except for a higher prevalence of obesity and diabetes in the NASH cohort. Post-prandially, RQ increased in both cohorts (i.e. greater carbohydrate utilization) but peak RQ and time at peak RQ was higher in the NASH cohort. Fasting RQ in NASH was significantly higher (0.845 vs. 0.772, p < .001), indicative of impaired FA utilization. In subgroup analysis of the NASH cohort, body mass index but not liver fat content (MRI-PDFF) was an independent predictor of fasting RQ. In NASH, fasting RQ inversely correlated with fat-free muscle volume and directly with visceral adipose tissue. Conclusion Reduced metabolic flexibility in patients transplanted for NASH cirrhosis may precede the development of non-alcoholic fatty liver disease after LT. Funding Agencies|CTSA awardUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [KL2TR002648]; National Center for Advancing Translational SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS)
Databáze:	OpenAIRE
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