Title- Genomic landscape of squamous cell carcinoma- Different genetic pathways culminating in a common phenotype
| Autor: | Allison M Lindsey, Robert J. Poppiti, Kritika Krishnamurthy, Mike Cusnir, Christie-Anne Estrada, Camila C Martinez, Vathany Sriganeshan, Michael Schwartz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cancer Research Notch Biology Tp53 mutation Genetic pathways DNA sequencing 03 medical and health sciences 0302 clinical medicine Next generation sequencing medicine Gene family Humans Basal cell Squamous cell carcinoma genetics Gene RC254-282 Aged Lung Crebbp Neoplasms. Tumors. Oncology. Including cancer and carcinogens Genomics Phenotype 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Female Tp53 |
| Zdroj: | Cancer Treatment and Research Communications, Vol 25, Iss, Pp 100238-(2020) |
| ISSN: | 2468-2942 |
| Popis: | Introduction: Squamous cell carcinomas (SqCCs) are the most common solid tumors in humans and are found across multiple organ systems. Although, integrated analysis of genetic alterations divulge similarities between SqCCs from various body sites, certain genes appear to be more frequently mutated in a given SqCC. These subtle differences may hold the key to determining the differentiation characteristics and predicting aggressiveness of tumors. Materials and Method: Fifty-four cases of SqCCs, in which the primary location of the tumor could be ascertained by clinical and radiological findings, were included in this study. Next generation sequencing data was analyzed for recurrent genetic abnormalities. Results: Genetic alterations were found in 219 genes in the 54 cases studied. TP53 mutations were found to be more frequent in pulmonary SqCCs (86.5%) as compared to non-pulmonary SqCCs (58.8%) (p |
| Databáze: | OpenAIRE |
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