The immunomodulatory effects of tachykinins and their receptors
| Autor: | Seyed Isaac Hashemy, Sahar Khorasani, Fahimeh Lavi Arab, Nadia Boroumand |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell type animal diseases Cell chemical and pharmacologic phenomena Inflammation Apoptosis Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Immune system Cell Movement Tachykinins medicine Leukocytes Animals Homeostasis Humans Receptor Molecular Biology Receptors Tachykinin Cell Proliferation Neuropeptides Cell Biology biochemical phenomena metabolism and nutrition 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation 030220 oncology & carcinogenesis Immune System bacteria medicine.symptom Neuroscience Function (biology) Signal Transduction |
| Zdroj: | Journal of cellular biochemistryREFERENCES. 121(5-6) |
| ISSN: | 1097-4644 |
| Popis: | Tachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non-neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune-related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of TKs intervention in the immune system would help to design novel therapeutic approaches for patients suffering from immune disorders. The present review summarizes studies on TKs function as modulators of the immune system by reviewing their roles in generation, activation, development, and migration of immune cells. Also, it discusses TKs involvement in three main cellular mechanisms including inflammation, apoptosis, and proliferation. |
| Databáze: | OpenAIRE |
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