Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis
| Autor: | Simona Feyereislova, Ladislav Krofta, Stranák Z, Jaroslav Feyereisl, Peter Korček |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
preterm labor
Calcitonin Fetal Membranes Premature Rupture medicine.medical_specialty Cord Placenta lcsh:Medicine Gestational Age Chorioamnionitis Gastroenterology General Biochemistry Genetics and Molecular Biology Procalcitonin 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Internal medicine medicine Humans 030212 general & internal medicine Retrospective Studies 030219 obstetrics & reproductive medicine Neonatal sepsis business.industry lcsh:R Pregnancy Outcome Gestational age Fetal Blood medicine.disease Cord blood Immunology early onset sepsis Premature Birth Female business Premature rupture of membranes procalcitonin intra-amniotic infection hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biomedical Papers, Vol 160, Iss 4, Pp 499-502 (2016) |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2016.041 |
| Popis: | Aims: To analyze the relationship between maternal, cord blood and neonatal procalcitonin (PCT) levels in preterm deliveries with and without histologically proven chorioamnionitis (HCA). Methods: 91 mother-infant pairs from 24+0 to 33+0 gestational weeks were analyzed. Procalcitonin was measured in all mothers within 24 hours before and subsequently in cord blood and in neonates within the first two hours after delivery. PCT levels were analysed in relationship to HCA and clinical outcome. Results: HCA was confirmed in 28 cases (31%). We found no differences in PCT values between HCA positive and negative groups in maternal blood (0.1±0.1 vs 0.09±0.09 ng/L, P = 0.76). PCT values in cord blood and neonates were significantly higher in the HCA positive compared to HCA negative group (0.23±0.1 vs 1.2±2.7 ng/L, P < 0.001 and 0.89±3.4 vs 4.2±9.3 ng/L, P < 0.0001 respectively). PCT values in neonates were significantly higher than those of cord blood. Levels were not influenced by the mode of delivery, gestational age or premature rupture of membranes. Chorioamnionitis was more frequently associated with early onset neonatal sepsis (36% in HCA group vs 5% in non HCA group, P < 0.0001). Comparison of other clinical data revealed no differences between HCA positive and negative groups. Conclusion: This study showed higher PCT in cord and neonatal blood in the presence of proven histological chorioamnionitis. The measurement of PCT in mothers' blood is not helpful for diagnosis of HCA. The changes in PCT values shown suggest its production and release by fetal tissue. |
| Databáze: | OpenAIRE |
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