Antigens of melanocytes and melanoma
| Autor: | Brigitte Bouchard, Hiroo Yuasa, Setaluri Vijayasaradhi, Alan N. Houghton, Sally A. Lynch |
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| Rok vydání: | 1991 |
| Předmět: |
Cancer Research
Melanoma Cellular differentiation Cell Differentiation Melanocyte Biology medicine.disease Antigens Differentiation Phenotype Malignant transformation Metastasis Cell Transformation Neoplastic medicine.anatomical_structure Oncology Melanocyte differentiation Antigens Neoplasm Tumor progression Immunology medicine Humans Melanocytes |
| Zdroj: | CANCER AND METASTASIS REVIEW. 10:141-150 |
| ISSN: | 1573-7233 0167-7659 |
| DOI: | 10.1007/bf00049411 |
| Popis: | Melanoma is a valuable model to study phenotypic traits that are regulated during cell differentiation and malignant transformation. Melanoma cells display extensive phenotypic and antigenic heterogeneity. Studies of this attribute have provided insight into events that take place during normal melanocyte differentiation and give clues to traits that contribute to malignancy. It is possible that the phenotypic and genotypic heterogeneity present among melanoma cells within a single lesion includes a subset of cells with traits that favor tumor progression and metastasis. This review discusses the identification and characterization of antigens expressed by melanoma cells and their potential contribution to melanocyte differentiation and malignant transformation. |
| Databáze: | OpenAIRE |
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