Targeted Drug-Resistance Testing Strategy for Multidrug-Resistant Tuberculosis Detection, Lima, Peru, 2005–2008
| Autor: | Gloria Yale, Sidney Atwood, Carmen Contreras, Jaime Bayona, Sonya Shin, Gustavo E. Velásquez, Hector O. Jave, Luis Asencios, J. Peter Cegielski, Martin Yagui, Carmen Suarez, Cesar Bonilla |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Tuberculosis Household contact Epidemiology testing strategy Antitubercular Agents lcsh:Medicine Microbial Sensitivity Tests Drug resistance lcsh:Infectious and parasitic diseases resistance Mycobacterium tuberculosis Drug Resistance Multiple Bacterial Internal medicine Peru Tuberculosis Multidrug-Resistant Isoniazid Prevalence medicine Humans Mass Screening lcsh:RC109-216 Mass screening Bacteria biology business.industry Research lcsh:R medicine.disease biology.organism_classification tuberculosis and other mycobacteria Surgery Multiple drug resistance Infectious Diseases Population Surveillance Practice Guidelines as Topic Rifampin MDR TB multidrug resistant tuberculosis Previously treated business medicine.drug |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 17, Iss 3, Pp 432-440 (2011) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Running head: Targeted Drug-Resistance Testing Strategy for MDR TB The Peruvian National Tuberculosis Control Program issued guidelines in 2006 specifying criteria for culture and drug-susceptibility testing (DST), including district-level rapid DST. All patients referred for culture and DST in 2 districts of Lima, Peru, during January 2005–November 2008 were monitored prospectively. Of 1,846 patients, 1,241 (67.2%) had complete DST results for isoniazid and rifampin; 419 (33.8%) patients had multidrug-resistant (MDR) TB at the time of referral. Among patients with new smear-positive TB, household contact and suspected category I failure were associated with MDR TB, compared with concurrent regional surveillance data. Among previously treated patients with smear-positive TB, adult household contact, suspected category II failure, early relapse after category I, and multiple previous TB treatments were associated with MDR TB, compared with concurrent regional surveillance data. The proportion of MDR TB detected by using guidelines was higher than that detected by a concurrent national drug-resistance survey, indicating that the strategy effectively identified patients for DST. |
| Databáze: | OpenAIRE |
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