Rodent Models of Optic Neuritis
| Autor: | Michael J. Levy, Yael Redler |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty genetic structures Central nervous system experimental autoimmune encephalomyelitis Review multiple sclerosis lcsh:RC346-429 Pathogenesis Optic neuropathy 03 medical and health sciences 0302 clinical medicine medicine Optic neuritis Young adult lcsh:Neurology. Diseases of the nervous system optic neuritis business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis medicine.disease rodent models eye diseases 030104 developmental biology medicine.anatomical_structure Neurology Optic nerve demyelination sense organs Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2020.580951 |
| Popis: | Optic neuritis (ON) is an inflammatory attack of the optic nerve that leads to visual disability. It is the most common optic neuropathy affecting healthy young adults, most commonly women aged 20-45 years. It can be idiopathic and monophasic or as part of a neurologic disease such as multiple sclerosis with recurrence and cumulative damage. Currently, there is no therapy to repair the damage from optic neuritis. Animal models are an essential tool for the understanding of the pathogenesis of optic neuritis and for the development of potential treatment strategies. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental rodent model for human autoimmune inflammatory demyelinating diseases of the central nervous system (CNS). In this review, we discuss the latest rodent models regarding optic neuritis, focusing on EAE model, and on its recent achievements and developments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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