| Autor: |
Asal Ghaffari Zaki, Seyed Mohammad Miri, Şeyma Çimen, Tuba Akgül Çağlar, Esra N. Yiğit, Mehmet Ş. Aydın, Gürkan Öztürk, Emrah Eroglu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. The genetically encoded biosensor SypHer3s showed that pH-Controleffectively acidifies cytosolic, mitochondrial, and nuclear pH exclusivelyin the presence of beta-chloro-d-alanine in living cellsin a concentration-dependent manner. The pH-Control approach is promisingfor investigating the ultralocal pH imbalance associated with manydiseases. CE254SWXHI ; NN254SWPZX ; CP254SWT2R |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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