Quadruple therapy versus standard triple therapy for eradication of Helicobacter pylori in Kuwait
| Autor: | Motaz Saad, Mohammad Malik, Ahmad Alfadhli, Imre Schmidt, Noha Asem, Jaber Al-Ali, Mohamed Alboraie |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urea breath test Population Chronic gastritis macromolecular substances Gastroenterology Young Adult Anti-Infective Agents Clarithromycin Metronidazole Internal medicine Organometallic Compounds medicine Humans Urea Prospective Studies Bismuth Subcitrate Potassium education Omeprazole Aged Carbon Isotopes education.field_of_study biology medicine.diagnostic_test business.industry Amoxicillin Middle Aged Tetracycline Helicobacter pylori Anti-Ulcer Agents bacterial infections and mycoses medicine.disease biology.organism_classification Breath Tests Kuwait Gastritis Chronic Disease Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | Arab Journal of Gastroenterology. 16:131-135 |
| ISSN: | 1687-1979 |
| Popis: | Background and study aims Chronic infection caused by Helicobacter pylori ( H. pylori ) is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Eradication of H. pylori reduces morbidity of chronic gastritis and incidence of gastric cancer in high-risk population. We aimed at testing the efficacy of clarithromycin-based triple therapy and bismuth-based quadruple therapy for eradicating H. pylori in patients with chronic gastritis in Kuwait. Patients and methods A total of 218 dyspeptic patients from different countries who were proved to have chronic gastritis by endoscopy and gastric biopsy were enroled. All of them were naive to H. pylori eradication therapy. They were randomised into two groups: group A, received triple therapy (omeprazole, amoxicillin, and clarithromycin) for 10 days; and group B, received quadruple therapy (omeprazole, bismuth subcitrate potassium, tetracycline, and metronidazole) for 10 days. All patients were tested for eradication of H. pylori by carbon-13 urea breath test 4 weeks after treatment. Results Total response rate of eradication therapy in both groups was 77.5% ( n = 169). However, group B ( n = 100) had a higher eradication rate (88%) than group A ( n = 118) (68.6%). H. pylori eradication rate was significantly higher in males (84.2%) than females (70.2%) in both groups ( p Conclusion Bismuth-based quadruple therapy is more effective as a first-line therapy than clarithromycin-based triple therapy for eradicating H. pylori in patients with H. pylori -related chronic gastritis in Kuwait. |
| Databáze: | OpenAIRE |
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