Obesity and cancer death in white and black adults: A prospective cohort study

Autor: Justin C. Brown, Shengping Yang, Emily F. Mire, Xiaocheng Wu, Lucio Miele, Augusto Ochoa, Jovanny Zabaleta, Peter T. Katzmarzyk
Rok vydání: 2021
Předmět:
Zdroj: Obesity (Silver Spring)
ISSN: 1930-739X
1930-7381
Popis: OBJECTIVE: Determine if race modifies the association between obesity and cancer death. METHODS: The Pennington Center Longitudinal Study included 18,296 adults; 35.0% male and 34.3% black. Body mass index (BMI) was calculated as weight indexed by the square of height (kg/m(2)). The primary endpoint was death from cancer. RESULTS: During a follow-up of 14.3 years, 346 cancer deaths occurred. Among men, race modified the association of BMI and cancer death (P(interaction)=0.045); compared to a BMI of 22 kg/m(2), a BMI of 35 kg/m(2) in white men was associated with a hazard ratio of 1.74 (95% CI: 1.38–2.21), in black men the hazard ratio was 0.64 (95% CI: 0.45–0.90). Among women, race did not modify the association of BMI and cancer death (P(interaction)=0.43); however, compared to a BMI of 22 kg/m(2), a BMI of 35 kg/m(2) in white women was associated with a hazard ratio of 1.42 (95% CI: 1.18–1.70), in black women, the hazard ratio was 0.99 (95% CI: 0.82–1.20). CONCLUSIONS: In this diverse cohort of adults, having obesity was associated with an increased risk of cancer death in white men and women. In contrast, having obesity was associated with a reduced risk of cancer death in black men and did not influence risk in black women.
Databáze: OpenAIRE
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