Relationship between in vivo mitomycin c exposure, sister chromatid exchange induction and in vitro mitogenic proliferation. I. Development of murine splenic cell system
| Autor: | Paul L. Mann, Edward L. Schneider, David Kram, Donald E. Kern |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Lipopolysaccharides
Aging Cell division Lipopolysaccharide Spleen Sister chromatid exchange Mitomycins Mice chemistry.chemical_compound In vivo Concanavalin A medicine Animals Crossing Over Genetic Phytohemagglutinins Dose-Response Relationship Drug biology Mitomycin C Molecular biology In vitro Mice Inbred C57BL medicine.anatomical_structure chemistry Immunology biology.protein Sister Chromatid Exchange Cell Division Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 17:195-201 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(81)90085-3 |
| Popis: | In vivo administration of mitomycin C (MMC) to C57BL/6J mice induced a rapid, initial suppression (24 hours post injection) of in vitro mitogenesis. This was followed by of the mitogen concentration-response curves were found of the three mitogens, phytohemagglutinin and concanavalin A, but not for lipopolysaccharide. By 144 hours post injection, the dose-response curves and magnitude of the responses had returned to approximately control (untreated) levels. This approach provides a model system for the functional assessment of in vivo cellular damage by MMC. |
| Databáze: | OpenAIRE |
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