Lobeline Effects on Cognitive Performance in Adult ADHD
| Autor: | Catherine A. Martin, Mark S. Kleven, Paul A. Nuzzo, Greg Guenthner, Linda P. Dwoskin, Sharon L. Walsh, Yolanda Williams, John D. Ranseen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Article Nicotine 03 medical and health sciences chemistry.chemical_compound Cognition 0302 clinical medicine Double-Blind Method Developmental and Educational Psychology Humans Medicine Attention 0501 psychology and cognitive sciences Lobeline Nicotinic Agonists Effects of sleep deprivation on cognitive performance Amphetamine Psychiatry Dose-Response Relationship Drug business.industry Methylphenidate 05 social sciences Clinical Psychology Improved performance Memory Short-Term Treatment Outcome chemistry Attention Deficit Disorder with Hyperactivity Impulsive Behavior Central Nervous System Stimulants Female business 030217 neurology & neurosurgery 050104 developmental & child psychology medicine.drug Clinical psychology |
| Zdroj: | Journal of Attention Disorders. 22:1361-1366 |
| ISSN: | 1557-1246 1087-0547 |
| DOI: | 10.1177/1087054713497791 |
| Popis: | Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted. |
| Databáze: | OpenAIRE |
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