Electrophysiological responses from intrinsically photosensitive retinal ganglion cells are diminished in glaucoma patients
| Autor: | Takeshi Morita, Yumi Fukuda, Manami Kuze, Mineo Kondo, Masahiko Ayaki, Kazuo Tsubota |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty genetic structures Electroretinogram (ERG) Glaucoma 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Ophthalmology Electroretinography Medicine Humans lcsh:QC350-467 Intrinsically photosensitive retinal ganglion cells (ipRGCs) Células ganglionares de la retina intrínsecamente fotosensibles (ipRGCs) Electrorretinograma (ERG) business.industry Intrinsically photosensitive retinal ganglion cells Middle Aged medicine.disease Healthy Volunteers eye diseases Electrophysiology lcsh:RE1-994 030221 ophthalmology & optometry Visual Field Tests Female Original Article sense organs business Erg 030217 neurology & neurosurgery Glaucoma Open-Angle Photic Stimulation Tomography Optical Coherence lcsh:Optics. Light Optometry |
| Zdroj: | Journal of Optometry, Vol 10, Iss 4, Pp 226-232 (2017) Journal of Optometry |
| ISSN: | 1888-4296 |
| Popis: | Purpose To record electroretinograms (ERGs) from intrinsically photosensitive retinal ganglion cells (ipRGCs) of glaucoma patients. Methods ERGs were recorded in 10 normal subjects and 15 patients with glaucoma. The ERG illumination system was built to achieve receptor-silent substitution, and comprised an optical diffuser and four-in-one light-emitting diodes. Results The ERG recordings of ipRGC from normal subjects showed an “on” response and an “off” response. The mean (±SD) implicit time for the on and off responses in normal subjects was 103.0 ± 24.9 and 337.9 ± 45.8 ms, respectively, with corresponding amplitudes of 7.7 ± 2.8 and 7.3 ± 3.4 μV, respectively. In glaucoma patients, the implicit time of the on and off responses was 135.0 ± 28.9 and 368.2 ± 17.3 ms, respectively. The corresponding amplitudes of the on and off responses in these patients were 0.47 ± 0.18 and 0.66 ± 0.32 μV, respectively. Conclusions The results demonstrate successful ERG recording of ipRGCs from advanced glaucoma patients, with marked reductions in amplitude, although not implicit time, compared with normal subjects. |
| Databáze: | OpenAIRE |
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