Risk Factors for Human Herpesvirus 8 Seropositivity and Seroconversion in a Cohort of Homosexula Men
| Autor: | Nicole H. T. M. Dukers, Thomas F. Schulz, Roel A. Coutinho, Maria Prins, Ronald B. Geskus, Neil Renwick, Jaap Goudsmit, G. J. Weverling |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Sexually transmitted disease Epidemiology Sexual Behavior Prevalence Antibodies Viral Cohort Studies Risk Factors Humans Medicine Risk factor Seroconversion Sarcoma Kaposi business.industry Incidence Incidence (epidemiology) virus diseases Homosexuality Odds ratio Herpesvirus 8 Human Cohort Immunology business Demography Cohort study |
| Zdroj: | American Journal of Epidemiology. 151:213-224 |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | Sexual and nonsexual modes of transmission of human herpesvirus 8 (HHV8) have been suggested, but specific routes remain unclear. Therefore, the objective of this study was to assess risk factors for HHV8 seropositivity and determine specific sexual practices associated with HHV8 seroconversion. Sera from 1,458 homosexual men (Amsterdam Cohort Study, 1984-1996) were tested for antibodies to HHV8 with a modified version of an enzyme immunoassay, using recombinant HHV8 lytic phase capsid (ORF65) and latent phase nuclear (ORF73) proteins. HHV8 seroprevalence at study entry was 20.9% (305/1,458); was highest among those with positive human immunodeficiency virus (HIV) status, no steady partner, and southern European or Latin American nationality; and increased with older age and higher number of sexual partners. During follow-up, 215 men seroconverted for HHV8 (incidence: 3.6/100 person-years). Both prevalence and incidence rates remained more or less stable during the study period. Orogenital insertive sex (odds ratio (OR) = 5.95; 95% confidence interval (CI): 2.88, 12.29) or orogenital receptive sex (OR = 4.29; 95% CI: 2.11, 8.71) with more than five partners in the past 6 months, older age (OR = 2.89; 95% CI: 1.13, 7.34, when older than 45 years), and preceding HIV infection (OR = 2.47; 95% CI: 1.53, 3.99) were independent predictors for HHV8 seroconversion. The authors found strong evidence for orogenital transmission of HHV8 among homosexual men. |
| Databáze: | OpenAIRE |
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