Local NSAID Gel (Eltenac) in the Treatment of Osteoarthritis of the Knee: A double blind study comparing eltenac with oral diclofenac and placebo gel
| Autor: | H Crone, B Forsskåhl, G Tamelander, J Sandelin, A Harilainen, P Hamberg |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Diclofenac Knee Joint Administration Topical Immunology Anti-Inflammatory Agents Administration Oral Thiophenes Osteoarthritis Placebo law.invention Double-Blind Method Rheumatology Randomized controlled trial Oral administration law Internal medicine Arthropathy medicine Humans Immunology and Allergy Aniline Compounds business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine medicine.disease Clinical trial Anesthesia Population study Female business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 26:287-292 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009749709105318 |
| Popis: | In a randomized, double blind, multicentre study with 4 weeks follow-up of 290 patients with osteoarthritis of the knee joint, a topical NSAID (eltenac) was compared with oral diclofenac and placebo. The main outcome, Lequesne's Index and pain by VAS showed no statistically significant differences between neither of the active treatments and placebo for the total study population. However, in patients with more severe symptoms, both active groups showed statistically significant differences to placebo. No severe adverse drug reactions were seen but the number of GI reactions were three times higher in the diclofenac group compared to the topical treatment. Local skin reactions were twice as frequent in the eltenac than in the placebo group. Taking into account the nature of the treatment for a chronic disease like OA, our results indicate that eltenac gel could be a safe alternative to oral NSAIDs. |
| Databáze: | OpenAIRE |
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