Cancer chemoprevention through Frizzled receptors and EMT
| Autor: | Meredith A. Tennis, A. Elango, Alex J. Smith, K. Sompel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Frizzled Epithelial to mesenchymal transition Endocrine and Autonomic Systems Endocrinology Diabetes and Metabolism Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Context (language use) Review Biology medicine.disease Molecular medicine Chemoprevention Endocrinology Oncology Cell surface receptor Surgical oncology Cancer research medicine Epithelial–mesenchymal transition Receptor RC254-282 |
| Zdroj: | Discover Oncology, Vol 12, Iss 1, Pp 1-15 (2021) Discover. Oncology |
| ISSN: | 2730-6011 |
| Popis: | Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing. FZDs are often associated with the process of epithelial to mesenchymal transition (EMT) through β-catenin, but some also influence EMT through non-canonical pathways. With ten different FZDs, there is a wide range of activity from oncogenic to tumor suppressive depending on the tissue context. Alterations in FZD signaling can occur during development of premalignant lesions, supporting their potential as targets of chemoprevention agents. Agonizing or antagonizing FZD activity may affect EMT, which is a key process in lesion progression often targeted by chemoprevention agents. Recent studies identified a specific FZD as important for activity of an EMT inhibiting chemopreventive agent and other studies have highlighted the previously unrecognized potential for targeting small molecules to FZD receptors. This work demonstrates the value of investigating FZDs in chemoprevention and here we provide a review of FZDs in cancer EMT and their potential as chemoprevention targets. |
| Databáze: | OpenAIRE |
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