ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses
| Autor: | Shehab Ismail, Laura Powell, John A. Sayer, Youhani H. Samarakoon |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Primary (chemistry) Immunological Synapses ADP-Ribosylation Factors Cilium Cell Membrane Cell Biology Mini-Review Biology Biochemistry Immunological synapse Cell biology 03 medical and health sciences 0302 clinical medicine Signalling Immune system 030220 oncology & carcinogenesis Animals Humans Small GTPase Cilia 030304 developmental biology |
| Zdroj: | Small GTPases |
| ISSN: | 2154-1256 2154-1248 |
| DOI: | 10.1080/21541248.2019.1703466 |
| Popis: | The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focusing lipids and proteins. ARL3, a small GTPase, plays a major role in concentrating lipid-modified proteins in both the immunological synapse and the primary cilia. Here in this review we will introduce the role of ARL3 in health and disease and its role in polarizing signalling at the primary cilia and immunological synapses. |
| Databáze: | OpenAIRE |
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