Leukotriene receptor antagonist addition to intranasal steroid: systematic review and meta-analysis
| Autor: | Kornkiat Snidvongs, Kachorn Seresirikachorn, K Limitlaohaphan, V Asvapoositkul, J Mullol |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Leukotriene receptor business.industry Antagonist General Medicine Rhinitis Allergic law.invention Otorhinolaryngology Quality of life Randomized controlled trial Adrenal Cortex Hormones law Internal medicine Meta-analysis Quality of Life Humans Leukotriene Antagonists Nasal steroid Medicine Steroids Nasal administration business Adverse effect Administration Intranasal |
| Zdroj: | Rhinology journal. 59:2-9 |
| ISSN: | 0300-0729 |
| Popis: | Background: Intranasal corticosteroids (INCS) and leukotriene receptor antagonist (LTRA) have different mechanisms of action. The combination of INCS and LTRA (INCS+LTRA) are utilized to control the allergic rhinitis (AR) symptoms. The effects of this com- bination have not been made evident yet. Methodology: Randomized controlled trials studying the effects of INCS+LTRA vs INCS in monotherapy on rhinoconjunctivitis symptoms in patients with AR were included. Data were pooled for meta-analysis. The outcomes were nasal symptoms, ocular symptoms, disease-specific quality of life (QOL), and adverse events. Results: Six studies (358 participants) met the inclusion criteria. There were no differences between INCS+LTRA and INCS mono- therapy on composite nasal symptom score, total daytime symptom score, total night time symptom score, disease-specific QOL and adverse events. The results favoured the effects of INCS-LTRA on ocular symptoms. Conclusions: The effects of the INCS+LTRA combination are not different from INCS in monotherapy in the improvement of both nasal symptoms and patient's QOL. The combination may, however, be better on improving ocular symptoms. |
| Databáze: | OpenAIRE |
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