Distribution of Amylin-Immunoreactive Neurons in the Monkey Hypothalamus and their Relationships with the Histaminergic System
| Autor: | Sunil J. Wimalawansa, Loredana D'Este, Tindaro G. Renda |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Amyloid medicine.medical_specialty Histology Hypothalamus Amylin Nerve fiber Histidine Decarboxylase Biology Immunoenzyme Techniques chemistry.chemical_compound Internal medicine medicine Animals Humans cardiovascular diseases Neurons Histaminergic Histidine decarboxylase Islet Amyloid Polypeptide medicine.anatomical_structure Endocrinology nervous system chemistry Median eminence Anorectic Macaca Biomarkers Histamine |
| Zdroj: | Archives of Histology and Cytology. 64:295-303 |
| ISSN: | 1349-1717 0914-9465 |
| DOI: | 10.1679/aohc.64.295 |
| Popis: | Amylin (AMY) is a 37 amino acid peptide of pancreatic origin that has been localized in peripheral and central nervous structures. Both peripheral and central injection of the peptide causes various effects, including anorectic behavior in rats. Prompted by previous reports showing that the anorectic effect of AMY is mediated by histamine release, we immunohistochemically investigated possible relationships between these two systems at the light microscopical level. Monkey (Macaca fuscata japonica) hypothalamus specimens were submitted to immunohistochemical double staining procedures using AMY and histidine decarboxylase (HDC) antisera. AMY-immunoreactive neurons were found widely distributed in several nuclei of the monkey hypothalamus including the supraoptic, paraventricular, perifornical, periventricular, ventro-medial, arcuate, and tuberomammillary nuclei. We detected AMY-immunoreactive nerve fibers throughout the hypothalamus, the median eminence and hypothalamus-neurohypophysial tract. Although AMY- and HDC-immunoreactive neuronal cell bodies occupied distinct hypothalamic zones, many HDC-immunoreactive cell bodies and dendrites, particularly those in the periventricular, arcuate, and rostral tuberomammillary regions, were surrounded by numerous AMY-immunoreactive nerve fiber varicosities. These findings demonstrate for the first time the presence of a discrete number of AMY-immunoreactive neurons in the monkey hypothalamus and add morphological support to the experimental data demonstrating that AMY probably exerts its influence on food intake via the histaminergic system. |
| Databáze: | OpenAIRE |
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