Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer
| Autor: | Strati, K., Lambert, P. F. |
|---|---|
| Přispěvatelé: | Strati, K. [0000-0002-2332-787X] |
| Rok vydání: | 2007 |
| Předmět: |
DNA Replication
Cancer Research Pathology medicine.medical_specialty Tumor suppressor gene Genes Viral animal experiment protein E7 protein E6 cancer cell culture medicine.disease_cause retinoblastoma protein Retinoblastoma Protein Article animal tissue Mice Wart virus medicine Humans Animals controlled study Papillomaviridae protein expression mouse nonhuman Oncogene biology virus carcinogenesis animal model Head and neck cancer transgene Retinoblastoma protein article Cancer Oncogenes medicine.disease biology.organism_classification Phenotype virus oncogene Oncology priority journal Head and Neck Neoplasms immunohistochemistry Cancer research biology.protein head and neck cancer Carcinogenesis |
| Zdroj: | Cancer research Cancer Res. |
| Popis: | Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). However, the individual consequences of E6 and E7 expression in an in vivo model have not been examined in these tissues. We have used transgenes that direct expression of the HPV16 E6 and E7 proteins to the head and neck tissues of mice to dissect the contribution of these proteins to head and neck carcinogenesis. We report here that E7 is the major transforming oncogene in HPV-associated HNSCC, whereas E6 is more likely to play a secondary role in contributing to later stages of carcinogenesis. Furthermore, a conditional deletion of Rb, a prominent target for E7, in the same tissues did not recapitulate all E7-mediated phenotypes. Although our results do not preclude an important role for the E7-pRb interaction, they highlight the importance of pRb-independent functions of E7 in head and neck carcinogenesis. [Cancer Res 2007;67(24):11585–93] |
| Databáze: | OpenAIRE |
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