Melatonin and alpha lipoic acid restore electrolytes and kidney morphology of lopinavir/ritonavir-treated rats
| Autor: | Elias Adikwu, Wolfe Atuboyedia Obianime, Nelson Brambaifa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Lopinavir/ritonavir Kidney lcsh:RC870-923 Antioxidants Melatonin Internal medicine Medicine Pharmacology (medical) Saline Protection Toxicity business.industry lcsh:RM1-950 Albumin Lopinavir lcsh:Diseases of the genitourinary system. Urology lcsh:Therapeutics. Pharmacology Endocrinology medicine.anatomical_structure Oxidative stress Nephrology Ritonavir business medicine.drug |
| Zdroj: | Journal of Nephropharmacology, Vol 9, Iss 1, Pp e06-e06 (2020) |
| ISSN: | 2345-4202 |
| Popis: | Introduction: Lopinavir/ritonavir (LPV/r) may cause renal dysfunction such as electrolyte and acid base disorders and alteration in kidney morphology. Drug–induced renal dysfunction can occur through multiple mechanisms including oxidative stress and inflammation. Objectives: The current study aimed at evaluating the protective effects of melatonin (MT) and alpha lipoic acid (ALA) against serum electrolytes and kidney histology of LPV/r-treated rats. Adult albino rats were randomized into six groups (A to F). Rats in the control groups were treated orally with normal saline and 1% ethanol as placebo and solvent control for 90 days respectively. Rats in the experimental groups were pre-treated orally with 10 mg/kg of MT, 10 mg/kg of ALA, and MT+ ALA daily before treatment with 22.9/5.71, 45.6/11.4 94 and 91.4/22.9 mg/kg/d of LPV/r for 90 days respectively. Materials and Methods: At the end of treatment, rats were euthanized. Blood samples were collected and serum samples were extracted and evaluated for electrolytes, total protein, and albumin. Additionally, kidneys were excised via dissection and evaluated for morphological changes. Results: Significant (P |
| Databáze: | OpenAIRE |
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