Vascular endothelial damage in COPD: current functional assessment methods and future perspectives
| Autor: | Dimitra Rafailia Bakaloudi, Konstantina Dipla, Afroditi K. Boutou, Marieta Theodorakopoulou, Andreas Zafeiridis |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Context (language use) Disease Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Endothelial dysfunction Cause of death COPD business.industry Smoking Public Health Environmental and Occupational Health medicine.disease Coronary arteries medicine.anatomical_structure Clinical research 030228 respiratory system Cardiovascular Diseases Arterial stiffness Cardiology Endothelium Vascular business |
| Zdroj: | Expert Review of Respiratory Medicine. 15:1121-1133 |
| ISSN: | 1747-6356 1747-6348 |
| DOI: | 10.1080/17476348.2021.1919089 |
| Popis: | Introduction: Cardiovascular disease is a major cause of death in chronic obstructive pulmonary disease (COPD), but the relationship between these two entities is not fully understood; smoking, inflammation, arterial stiffness and endothelial dysfunction are significant determinants. Endothelial dysfunction is not only associated with cardiovascular disease, but also with COPD severity.Areas covered: Several functional methods have been developed to evaluate endothelial function in healthy and diseased individuals; from the invasive angiography of epicardial coronary arteries and Venous-Occlusion-Plethysmography, to more modern, noninvasive approaches such as Flow-Mediated-Dilatation, Peripheral-Arterial-Tonometry and Near-Infrared-Spectroscopy, all these methods have boosted clinical research in this field. In this context, this narrative review, which included articles published in PubMed and Scopus up to 25-November-2020, summarizes available functional methods for endothelial damage assessment in COPD and discusses existing evidence on their associations with comorbidities and outcomes in this population.Expert opinion: Accumulated evidence suggests that endothelial dysfunction occurs in early stages of CΟPD and worsens with pulmonary obstruction severity and during acute exacerbations. Novel methods evaluating endothelial function offer a detailed, real-time assessment of different parameters related to vascular function and should be increasingly used to shed more light on the role of endothelial damage on cardiovascular and COPD progression. |
| Databáze: | OpenAIRE |
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