Hemoadsorption: effective in reducing circulating fragments of the endothelial glycocalyx during cardiopulmonary bypass in patients undergoing on-pump cardiac surgery?
| Autor: | Andreas Hohn, Jochen Hinkelbein, Dirk Buchwald, Thorsten Annecke, Jeremy Franklin, Peter K. Zahn, Eva Pietroschinsky, Andreas Baumann, Anja Illerhaus |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cardiopulmonary Bypass business.industry Ischemia Pharmacology Hypoxia (medical) Glycocalyx medicine.disease Endothelial glycocalyx Cardiac surgery law.invention Anesthesiology and Pain Medicine Cardiac Surgery procedures law medicine Cardiopulmonary bypass Humans In patient Endothelium Vascular Heparitin Sulfate Cardiac Surgical Procedures medicine.symptom business |
| Zdroj: | Minerva Anestesiologica. 87 |
| ISSN: | 1827-1596 0375-9393 |
| Popis: | BACKGROUND The vascular endothelial glycocalyx is susceptible to ischemia and hypoxia. Released soluble components of the endothelial glycocalyx (EG) have been identified as potential damage associated molecular patterns (DAMPs) able to enhance an ongoing inflammatory response. Shedding of the EG has been associated with released atrial-natriuretic peptide (ANP) during cardiac surgery procedures. A novel hemoadsorption technique (CytoSorb®) has been shown to effectively remove molecules up to 55 kDa unspecifically from circulation. It is not known whether ANP or glycocalyx components can be removed successfully by this technique. METHODS In 15 patients undergoing on-pump cardiac surgery, the hemoadsorption device was integrated in the cardiopulmonary bypass (CPB) circuit. Pre- and post-adsorber concentrations of ANP, heparan sulphate (HEP), syndecan-1 (SYN) and hyaluronan (HYA) were measured at 10 (T1), 30 (T2), and 60 (T3) minutes after aortic cross-clamping and complete CPB. RESULTS Hemoadsorption significantly reduced mean HEP concentrations (-157.5 [333.4] ng/mL; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|